Unfortunately, Washington DC does not have any representatives in the US Senate. If that were the case, I'd be in favor of Michelle Obama running for the position in the next election (which could be 2014). Alas, that is not the case.
So...I suggest she should do two things:
One...make it known to Illinois Governor Pat Quinn that she wants the open Senatorial seat in the event that Senator Mark Kirk is forced to resign as a result of the stroke he suffered in January of 2012. Also, I suppose it's possible to remove him from office since it's already nearly a year that he's been out of work.
Two...make it known that she will be running for that same position in 2016.
Even if Senator Kirk steps down (or is removed) sooner rather than later, I believe the Obamas will find a way to make it work for their family during several stressful years of transition.
Barack Obama will be out of office in 2016 and they will likely move back to the Chicago area. It's Michelle's turn!
In fact, it's also Hillary Clinton's turn. Hopefully, she'll choose to run for President in 2016 (rather than settle in as Mayor of New York).
One can dream, eh? President Hillary Clinton...Senator Michelle Obama. It just sounds right!
Yee gods! If Michelle Obama plays her card right, she could be President in 2024! She'd only be sixty, right?
Indeed, one can dream. It just feels right. (I certainly don't want any of those conservative 'wack-jobs' stepping in to start new wars, deplete my Social Security and further destroy our economy.)